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For instance, liproxstatin-1 suppresses ferroptosis by lowering ACSL4 levels in the RPEBruchs membranechoroid complex, effectively halting DR progression (37, 38)

Sci Rep 9:3895

Novel insights into the role of mitochondria in diabetic cardiomyopathy: molecular mechanisms and potential treatments

23 ABCG5 and ABCG8 genes in the STSL locus on chromosome 2p21 encode proteins sterolin-1 and sterolin-2, respectively, which together form a heterodimer pair expressed on the canalicular hepatocyte membrane and are involved in the transport of hepatobiliary cholesterol from hepatocytes into the bile canaliculi

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Despite these manifold and potent metal chelation systems, ROS are formed continuously in the body, both by enzymes and spontaneous metal-catalyzed reactions