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ATP, the intracellular energy currency molecule, has been shown to act as a biological hydrotrope to prevent pathological protein aggregation and maintain protein solubility (46), while elevated MDA levels are associated with cataract formation (47)

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Furthermore, GPx3 deficiency in patients has been linked to increased OS, endothelial dysfunction, coronary thrombosis, and diminished left ventricular function [113, 114]

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In certain embodiments, any controlled-release otic formulation described herein alters (e.g