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These changes facilitate the translocation of gut-derived endotoxins (e.g., LPS) and pathological proteins (e.g., -synuclein) into systemic circulation, subsequently activating peripheral immune responses 31,36

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Similarly, the co-cultivation of a folate producer, Lactobacillus plantarum , with a vitamin B 12 producer, Propionibacterium freudenreichii , in a whey permeate medium led to a natural dietary supplement with an optimal ratio of folate and vitamin B 12 146,847,848,849,850,851,852

They observed a direct correlation between the levels of carbonyl moieties, an indicator of protein oxidation, and the severity of the lesion