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In depression, neuroinflammation is induced by psychosocial stress through various mechanisms including activation of microglia, activation of the sympathetic nervous system (SNS), and glucocorticoid resistance (Miller and Raison, 2016

Sleep deprivation elevates the production of NO and RNS, which catalyze the nitrosylation of crucial proteins, including the N-ethylmaleimide sensitive factor (NSF) and postsynaptic density-95 (PSD-95)

Palacios, S

Emerging evidence revealed that vitamin A in pharmacological doses or prolonged consumption could promote tumor progression and increase the risk of cancer mortality via a prooxidant effect [62]

This dynamic resolution also underscores the limitations of urinary analysis, such as 24-hour urinary free cortisol or catecholamines