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[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Cheyssac C, Lecoeur C, Dechaume A, et al

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Mechanistically, permeation enhancement is typically achieved through transient modulation of epithelial tight junctions to increase paracellular transport, alteration of membrane organisation to facilitate transcellular diffusion, and may also influence local mucus-drug interactions or enzymatic stability depending on excipient chemistry and exposure profile (Maher et al., 2019)

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