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The dominant L MW SS within tissues was GSS , consistent with the far higher levels of GSH compared to other L MW thiols

Specifically, we administered a series of doses of rosiglitazone or WY-14643 (25 mg/kg body weight, 12.5 mg/kg body weight, 6.25 mg/kg body weight, 3.125 mg/kg body weight) via i.p

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This theory was first experimentally confirmed in the 1980s by the laboratory of Eric Newsholme (19352011, widely accepted now as the origin of hypotheses and evidence for the concept of immunometabolism) [3,7] in the University of Oxford, and subsequently by many other laboratories worldwide [4,8,9]