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This study found a marked expression of monocyte-chemoattractant protein (MCP)-1, macrophage-inflammatory protein (MIP)-1 , MIP-1 , interferon- -inducible protein (IP)-10, interleukin (IL)-8, and RANTES in varicose veins, suggesting that chemokines might play an important role in their pathophysiology by recruiting leucocytes to the vein wall and contributing to inflammation and edema

[PubMed] [Google Scholar] 241.Yokoyama A, Takagi T, Ishii H, Wada N, Maruyama K, Takagi S, Hayashida M

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AOD-9604 does have real attributes: its safety profile across six trials (893 participants) was essentially clean, with adverse events indistinguishable from placebo