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20 mg/kg/day in some earlier positive studies)

Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms

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Your Path to Peace of Mind If you've been spiraling on the question can claritin cause heart palpitations, the evidence points in a reassuring direction

In healthy populations with adequate levels, the evidence tends to be more heterogeneous, so absolute conclusions should be avoided

[1] Unlike amphetamine abuse, where drug tolerance necessitates escalating doses to achieve the same effect, tolerance to clinically relevant doses of amphetamine plateaus after the initial titration period, and "drug holidays" (i.e., temporary treatment discontinuation) are not required to prevent the development of tolerance