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Decreased activity of complexes I and II is closely associated with reduced ATP production in cardiomyocytes of male obese rats with IR (117), and the inhibition of cytochrome c oxidase and complex IV deteriorates dysfunctional mitochondria and decreases ATP levels (118)

Due to its organic chelate structure, the fumarate salt exhibits superior stability in tablet formulations with reduced oxidation rates, less discoloration during storage, and improved compatibility with other nutrients in multi-vitamin formulations

Electrical impedance myography (EIM) is a noninvasive measure of muscle via low-intensity current to detect changes in impedance over time [69]

doi: 10.1161/atvbaha.119.313414 105 ZhangW.MiikedaA.ZuckermanJ.JiaX.CharugundlaS.ZhouZ.et al