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Chemotherapy de-escalation using an (18)F-FDG-PET-based pathological response-adapted strategy in patients with HER2positive early breast cancer (PHERGain): a multicentre, randomised, open-label, non-comparative, phase 2 trial

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If the pH is too high (greater than 4.5), the protease enzymes are not activated.[3] This prevents the body from breaking down the protein into amino acids

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