glp-1/gip receptor agonist GIP Agonism Attenuates GLP-1 Receptor Induced Nausea and Emesis in Preclinical Models — Hayes Lab Science Behind GLP 1 GIP

2019;139:e56-528

When prescribing is supervised and thoughtful, these medicines are effective and safe. Louwagie agrees that the case report highlights the need for individualized care

Contrave (naltrexone/bupropion) combines an opioid antagonist with an antidepressant

Although some studies have raised concerns about pancreatitis and thyroid-related risks, the current evidence does not conclusively establish causality

Neuroinflammation in Depression and Its Relation to GLP-1 The immune system in the CNS has been shown to regulate brain development, neurogenesis, mood, and behavior (Zheng et al., 2016

A further study presented at Digestive Disease Week 2025 of 993 patients found GLP-1RA to be associated with a statistically significant increase in clinical remission rates (HBI or Mayo score) at 3 months numerical at 6 and 12 months without an increase in side-effects