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The phase 3 SURMOUNT programme assessed the safety and efficacy of tirzepatide as obesity treatment and the medication has now been approved (November 2023) for chronic weight management by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) [46, 47]

Nature 509 , 612616 (2014) Conlon, B

Caution is also advised in cases of hepatic impairment

10.1159/000346195 46 GorlovaO.MartinJ.-E.RuedaB.KoelemanB

18 (1) e70072

Subsequently a large series of tetrazole derivatives were prepared and examined ( 41 , that is a competitive inhibitor of IRAP and exhibits an IC50 of 540 nM in a recombinant human IRAP assay