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The interplay between DAA therapy and the influence on immune response particularly T cell exhaustion is still an opening question

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Dambrova M, Zuurbier CJ, Borutaite V, Liepinsh E, Makrecka-Kuka M

Due to the higher complexity of the hMSC functional assay compared to molecular-level nuclear receptor transactivation assays, the relatively longer duration, and associated higher implementation cost, we recommend a smaller set of well-characterised prototypical chemicals, including limited pharmaceuticals, as a first tier of adipogenesis test method optimisation and proficiency testing, to demonstrate the robust performance of an assay