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Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/-synuclein aggregation

It is not yet well-understood how these bacteria can exert these benefits, but documented mechanisms of action include antimicrobial activity against major gastrointestinal 171 and urogenital pathogens 172 , barrier-promoting effects at the gut epithelium 173 and other mucosa 174 , immunomodulatory effects by stimulating host antimicrobial compounds such as - defensins 175 and modulating the secretion of cytokines such as IL-10, IL-6, IL-1b, IL-2, TNF-, and impacting different cell types such as intestinal epithelial cells, dendritic cells, macrophages and regulatory T cells 176,177,178

This is accomplished by developing generalized robust models, that minimize bias, along with explained machine learning techniques for multifactorial longitudinal data to analyze in more accurate manner and ensure future research success

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