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365 Although kifunensine has been described as a suppressor of the UPR in several studies, it is more likely that it reduces the perceived level of ER stress by preventing misfolded glycoproteins from being recognized as defective, thereby limiting their degradation through the ERAD pathway

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The nuclear factor erythroid 2-related factor 2 ( NFE2L2 or NRF2) transcription factor is constitutively activated in many cancers and promotes a specific gene expression program involved in cellular detoxification, redox buffering, and metabolic rewiring (Cancer Genome Atlas Research, 2012

Interface 9 , 147157, (2011)