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Consider periodic monitoring of B12 in patients on metformin with risk factors for B12 deficiency Risk factors are quite wide-ranging and include the following (MHRA, 2022): Baseline vitamin B12 levels at the lower end of the normal range

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Cold, dry weather and overexposure to water can exacerbate the condition, according to Joshua Zeichner, M.D., director of cosmetic and clinical research in dermatology at Mount Sinai Hospital in New York City

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We monitor patients and adjust protocols based on response

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