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Human subjects Fresh CRC tissues and matched adjacent normal tissues used for the isolation and culture of fibroblasts and organoids were obtained from patients undergoing surgical resection at the Department of Gastrointestinal Surgery IV, Peking University Cancer Hospital & Institute

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As an integrative supportive therapy alongside conventional care, glutathione can help protect healthy tissue, support detoxification, and improve overall resilience

Peptides, simply put, are a string of amino acids

For immunofluorescence staining, brain tissues were dissected out, post-fixed by 4% paraformaldehyde (PFA) for 12 h, embedded in paraffin, cut into 5 mm sections and mounted on slides for subsequent staining

NNMT is predominantly expressed in the liver