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However, because this product provides doses far above the daily nutritional requirements (for instance 100 mg of B vs an RDA of ~1.4 mg), its use in pregnancy must be carefully considered

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Metabolites in pentose phosphate pathway are abundant, probably due to demand for antioxidants, NADPH, gluconeogenesis and anabolic metabolism

For example, the transcription factor Nrf2 binds to the antioxidant response element in the promoter region of SLC7A11 and then upregulates its expression [33]

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Here is what to do if you suspect an overdose If you suspect that you have taken too much B12, you may be experiencing the symptoms we have listed above