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When the peptide stimulates lipolysis and releases fatty acids from adipocytes, those fatty acids must be oxidized by other tissues to prevent them from being re-esterified and stored again

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In addition, GCN2 knockout mice fed a leucine deficiency diet show more severe effects on new born mouse viability compared with tryptophan or glycine deficiency diets (Zhang et al., 2002)

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Anderson RM, Barger JL, Edwards MG et al (2008) Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response