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Serological studies reveal a high prevalence of nAbs: approximately 67% of individuals have antibodies against AAV1, 72% against AAV2 [86], 47% against AAV9, 46% against AAV6, 40% against AAV5, and 38% against AAV8 [88] (Table 1) [89].These findings show the predominance of seropositive patients, which excludes them from gene therapy or prevents repeated administration in cases where initial dosing was insufficient or efficacy decreased over time [90]

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protein-coupled receptor kinases (GRKs) to G protein-coupled receptors

114, July 2020, p

J Immunol (2013) 190(8):431523

[DOI] [PubMed] [Google Scholar] 146.Bertolini TBB, Kaczmarek M, Daniell R, Herzog H, R