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Data availability The TCGA RNA-seq gene expression data were downloaded from The Cancer Genome AtlasData Portal The RNA-seq data of different human liver cancer cell lines were downloaded from Broad Institute Cancer Cell Line Encyclopedia (CCLE, file name: CCLE_RNAseq_rsem_genes_tpm_20180929.txt.gz) and from Liver Cancer Model Repository (LIMORE, download link: Gene expression profiles of 81 cell lines)

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IGFBP-3 proteolysis has also been described in insulin resistant states such as fasting, obesity and type 1 and 2 diabetes (62, 124, 125)

Variability of active cervical range of motion within and between days in healthy participants: A prospective observational study

Its dual role in canceracting as both a protector and a potential promoter of tumor growthhighlights the complexity of its functions in the body

range 160-296g) initially did weigh more than females (183.6g