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By delineating the copper-PDK1-AKT/-catenin-TCF4-ATP7B axis, the study provides a mechanistic foundation for combining Wnt inhibitors with copper ionophores to target therapy-resistant malignancies

In animal models of TBI, including both mice and larger pig models, CAQK reduced inflammation and cell death while improving memory and motor function

For a typical IgG with a molecular weight (MW) of 150,000, this value corresponds to a molar extinction coefficient () of 210,000 M -1 cm -1

Engel for her help in managing administration, English language correction and the reference list during the writing of this article

DAPI was used for nuclear staining

Multiple growth factors and oncogenic signals positively regulate GLUL transcription (van der Vos et al , 2012