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Dosage should begin at 50 mg/kg/day

Regarding the type of AEs, 18 patients (13.1%) reported insomnia, 15 patients (10.9%) reported widespread shivering, 10 patients (7.3%) reported headache, and 5 patients (3.6%) reported nausea (Table 3)

[ [PMID: 33257876] [33] Hirabara, S.M

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Frataxin deficiency is associated with imbalances in iron-sulfur containing proteins, mitochondrial respiratory chain dysfunction and lower ATP production, and accumulation of iron in the mitochondria, which increases oxidative stress and oxidative damage to macromolecules of the respiratory chain (77)