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Statements Author contributions YJ: Conceptualization, Investigation, Visualization, Writing original draft

They also acknowledge that this level of complex and sustained treatment may be impossible for many families to take on

Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7h-pyrrolo[2,3-d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity

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