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The positive correlation between TMAO and markers of inflammation and endothelial dysfunction in HF supports the notion that, beyond the traditional gut hypothesis of HF, additional mechanisms by which GMB alterations affect cardiac function and prognosis exist

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[DOI] [PubMed] [Google Scholar] 7.Fombonne E

1 Environmental or metabolic stressors, including nutritional state, physical activity, hormonal regulation, and pathological conditions such as heart failure, cancer cachexia, and chronic liver disease, require appropriate fuel selection to maintain metabolic homeostasis

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Todorova V, Blokland A