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Resistance to mTORC1 inhibitors, such as temsirolimus involves an upregulation of glutamine metabolism, PTEN expression, alteration of the p53 response to nucleolar stress, a negative feedback activation of the PI3K/AKT signaling, increased rates of clonal and non-clonal chromosome aberrations, and changes in the copy number alterations pattern [412,413,414]

[DOI] [PubMed] [Google Scholar] 42.Veith A., Moorthy B

In that study, it was also indicated that this technology allows obtaining mass spectra for biopolymers including oligonucleotides and proteins, the latter having molecular weights up to 130,000, with as yet no evidence of an upper limit (Fenn et al., 1989)

[DOI] [PubMed] [Google Scholar] 14.Huo M., Wang Y., Yuan X., Yuan Y., Zhang X

Fur, the above-mentioned global regulator of iron homeostasis, which exerts its function also indirectly controlling the expression of small regulatory RNAs

GLP-1 RAs may inhibit retinal neurodegeneration and reduce proinflammatory processes, which could protect against diabetic retinopathy progression