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H3K18la directly activates pore membrane protein 121 (POM121) transcription, which enhances MYC nuclear transport and direct binding to the CD274 promoter to induce PD-L1 expression in NSCLC cells, thereby causing CD8 + T-cell dysfunction and promoting immune evasion of NSCLC

[PMC free article: PMC5314136] [PubMed: 28209220] 656

The certainty of results is moderate, indicating a possible benefit of L-carnitine in this context

To this end, we employed a multi-pronged strategy, which involved proteomics analysis, genetic screening, in silico binding, sequence motif validation, and in vitro confirmation

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Shoja MM, Oyesiku NM, Shokouhi G, Griessenauer CJ, Chern JJ, Rizk EB, Loukas M, Miller JH, Tubbs RS