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Bone, 24 (3), 195-202
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The 300-mg maintenance dose group had a higher percentage of serious AEs than the 100-mg maintenance dose group during the initiation and maintenance periods, but this percentage was comparable to placebo treatment during the corresponding period (Table 3)
It also demonstrates protective antioxidant effects by lowering malondialdehyde (MDA), a cytotoxic lipid peroxidation product linked to carcinogenesis [81, 82]
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