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The handful of studies sometimes cited as human evidence are largely case reports or small, uncontrolled pilot studies
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This dual role means that BDNF modulation for pain requires careful consideration of the target tissue
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When (and When Not) to Use CPT 96372 Context also really matters as using code may be simple but when to use it, it confuses

Agrawal R, Zhuang Y, Cummings BP et al (2014) Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes
