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In LAB, genetic loci specifically induced by gut transit are those involved in nutritional adaptation (hydrolases, ABC transporters, and PTS systems) but also in anti-stress mechanisms such as membrane modification, surface glycosylation and anti-oxidative defences (Lebeer et al., 2011)

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Dietary-induced models, which mimic obesity and insulin resistance through high-fat, high-carbohydrate, or nutrient-deficient diets, often fail to reproduce the inflammation and fibrosis typical of advanced human MASLD

Trends Food Sci Technol 83:129137

Myogenic responses are important for the development of basal tone upon which other mechanisms exert vasoconstrictor and vasodilator influences (505), and thus play an important role in the regulation of CBF, which goes largely beyond the adaptation of CBF to changes in BP (autoregulation)

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