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Biochimica Et Biophysica Acta Bioenerget 1757(910):14211428

The structural difference between the two compounds helps explain this receptor selectivity divergence

These effects were more prominent in rats, more robust after bolus injection, and attenuated after repeated dosing
PMID: 39482325
While the activity of NHR-49 is regulated at multiple levels including cofactor interactions, heterodimerization with other nuclear receptors, and isoform-specific subcellular localization 23,42,45,46,47,48 , nuclear hormone receptors are classically defined as ligand-regulated transcription factors 49,50,51,52,53

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