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We also show that the skull bone is permeable to small-molecular-weight compounds, and use this delivery route to modulate inflammation and therapeutically ameliorate brain injury through transcranial administration of the ROS scavenger, glutathione

111skin ( 5,250B) 1 1 5,250 555555 NAC Y2 L-Glutathione (Reduced) for 30++ 30++ :

Long-term continuous use lacks safety data, so periodic breaks are generally recommended

doi: 10.1021/jf2000103

The DP-specific Corin-cre (Corin tm2Bamo ) mouse was previously generated 25 and kindly provided by Bruce Morgan (Harvard medical school)

Notably, MOTS-c treatment enabled old mice to outperform untreated middle-aged mice, suggesting a more pervasive physical reprogramming rather than just rejuvenation