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Consistent with reports in other cancer types showing that GPX2 overexpression promotes cisplatin resistance by suppressing ROS accumulation, our findings suggest that NAC-associated upregulation of GPX2 may enhance intracellular antioxidant defenses, thereby promoting survival of residual tumor cells and contributing to chemoresistance [21, 22]

Plasmids CRISPRCas9 sgRNA vectors targeting 2M and ABHD11 were previously generated by the laboratory 16

Days 2-4: S1 + Activin A

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& Jin, J

doi: 10.1017/S0007114516001811
