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SSC-A and the Hoechst-3342 signal was used for cell DNA content assessment and exclusion of doublets

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Model analysis Selection of parameters for estimation The methodology to select parameters for estimation involves first conducting local sensitivity analysis (LSA) to obtain a set of important parameters, and then determining from this set of parameters which are identifiable, that is for which parameters a value can be identified from the data, taking into account the model structure

At the pathological level, DM exerts multifaceted effects on pulmonary function through multiple mechanisms, including inflammatory responses, altered immune regulation, and pulmonary microvascular dysfunction (Tiengo et al., 2008