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Summary: Low B12 commonly causes neurological symptoms (pins and needles, balance problems, memory issues) and haematological features (fatigue, breathlessness, sore tongue), which may develop gradually over months

What patients notice first depends on their individual baseline

The compound's primary target, NNMT, sits at a critical metabolic intersection where NAD+ precursor availability meets cellular methylation capacity

This is the phase where the synergistic effects become most apparent

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However, if there are neurological symptoms that have arisen due to B12 deficiency, they could take up to three months to improve, with mild improvements occurring in the first six weeks