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Furthermore, coffee enemas followed by a healthy diet to put the good stuff back into the gut, can help to restore the bodys essential defenses, ensuring a stronger, more resilient system capable of maintaining health and preventing illness

The induction of targets, such as GCL, requires the activation of upstream transcriptional co-activators

Copper is an essential trace mineral used by the body in enzymes involved in connective tissue support and antioxidant defense

Given these limitations, targeting trained immunity provides a novel therapeutic perspective

1/ How sugar acts on the body Drives rapid glucose absorption Triggers insulin spikes and dips Promotes liver fat synthesis (fructose de novo lipogenesis) Increases hunger and cravings Alters gut microbiome balance Stimulates chronic inflammatory signals 2/ When sugar causes harm The harm comes from chronic high intake of added and free sugars, especially in: Insulin resistance Sedentary lifestyle Central obesity Chronic sleep disruption Micronutrient deficiency Metabolic syndrome Liquid sugars (SSBs, juices, syrups) are the strongest offenders They bypass satiety, overload the liver, and are consistently linked to: Type 2 diabetes NAFLD Hypertension Cardiovascular disease Stroke Higher all-cause mortality 3/ What the evidence says Recent umbrella and systematic reviews confirm: Sugar-sweetened beverages significantly increase T2DM and CVD risk Fructose in whole fruit is not harmful Liquid sugars drive visceral fat and liver fat Risk is independent of weight or calories The harm is metabolic, not just caloric 4/ Whole fruit vs added sugar Whole fruits contain sugar but also: Fibre Polyphenols Vitamins and minerals Slower absorption Theyre associated with: Lower inflammation Reduced CVD and diabetes risk Improved glycaemic control, even in those with metabolic syndrome But quantity matters

The phylogenetic tree was decorated with Interactive Tree Of Life (iTOL) V5 (Letunic and Bork, 2021)