glutathione rapta c Altered DNA Binding and Amplification of Human Breast Cancer Suppressor Gene BRCA1 Induced by a Novel Antitumor Compound, [Ru(η6-p-phenylethacrynate)Cl2(pta)] responsible for keeping cells protected from free Enhanced Delivery of the RAPTA-C
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[DOI] [PMC free article] [PubMed] [Google Scholar] Badwey J
![glutathione rapta c Altered DNA Binding and Amplification of Human Breast Cancer Suppressor Gene BRCA1 Induced by a Novel Antitumor Compound, [Ru(6-p-phenylethacrynate)Cl2(pta)] responsible for keeping cells protected from free Enhanced Delivery of the RAPTA-C](https://pubs.acs.org/cms/10.1021/bm4013919/asset/images/medium/bm-2013-013919_0011.gif)
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This suggests that lactate accumulation in severely degenerated discs may further impair cell function
![glutathione rapta c Altered DNA Binding and Amplification of Human Breast Cancer Suppressor Gene BRCA1 Induced by a Novel Antitumor Compound, [Ru(6-p-phenylethacrynate)Cl2(pta)] responsible for keeping cells protected from free Enhanced Delivery of the RAPTA-C](https://www.researchgate.net/publication/44579667/figure/fig4/AS:349450833809419@1460326979428/Structural-variations-of-the-ligands-in-the-lead-compound-RAPTA-C.png)
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Gujral JS, Knight TR, Farhood A, Bajt ML, Jaeschke H
![glutathione rapta c Altered DNA Binding and Amplification of Human Breast Cancer Suppressor Gene BRCA1 Induced by a Novel Antitumor Compound, [Ru(6-p-phenylethacrynate)Cl2(pta)] responsible for keeping cells protected from free Enhanced Delivery of the RAPTA-C](https://ars.els-cdn.com/content/image/1-s2.0-S0020169325004141-ga1.jpg)