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When the antioxidant defense system fails to effectively eliminate ROS, these oxidants accumulate precipitously (100), leading to elevated intracellular oxidative stress, which subsequently triggers cuproptosis

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Beyond this, it attenuates mitochondrial ROS generation by optimizing ETC coupling and preventing cardiolipin peroxidation (215)

Further studies and additional models are needed to clarify whether this reflects increased toxicity or immune activation
