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hPrdx6 is a prime example of the moonlighting protein exhibiting location specific multi-functionality

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doi: 10.1016/j.cell.2008.02.046 3 MolofskyAVKelleyKWTsaiH-HRedmondSAChangSMMadireddyLet al

Large, well-controlled studies in healthy adults are sparse, making broad wellness claims difficult to support with rigorous evidence

When ATP level is low (thus AMP/ATP ratio is high), AMPK is activated and protein synthesis, which consumes ATP, inhibited

In the case of insulin, L-arginine increased its concentration in the blood of treated rats with diabetes compared to untreated rats and in healthy supplemented rats