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Rhonda: Aerobic exercise (which is what endurance training is) has been shown to increase the growth of new neurons in the brain by two-fold 1 The Effects of Aerobic Exercise Intensity and Duration on Levels of Brain-Derived Neurotrophic Factor in Healthy Men Schmolesky et al

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Some of these mediators are also activated by the hypoxia inducible factor (HIF)[40-43]

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163 On the other hand, COX-2 is generally synthesized in response to inflammatory stimuli in many tissues including prostate, immune cells (T-cells, B-cells, monocytes), and stomach, but is also constitutively expressed in the brain, lungs, gut, thymus, kidneys, and blood vessels

In addition, Matsumura and co-workers 25 have reported that polyampholytes which possess strong affinity to plasma membranes act as good cryoprotectans