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In line with our findings, additional accounts of statin-induced cell death in vitro are primarily restricted to lipophilic statins, and the effect has been attributed to reactive oxygen species generation and depletion of metabolites like mevalonate and IPP, which are critical for isopentenylation and maintenance of GPX4 abundance [4852]

Fraternale A, Paoletti MF, Casabianca A, Oiry J, Clayette P, Vogel JU, Cinatl J Jr, Palamara AT, Sgarbanti R, Garaci E, Millo E, Benatti U, Magnani M

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[39] investigated hesperidins potential as an inhibitor of SARS-CoV-2 infection, shedding light on its novel therapeutic implications

Regardless of the route, changes in membrane potential and protein release are significant apoptotic events
