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GLP-1 Secretion While GLP-1 secretion was originally described in response to glucose, it also occurs with ingestion of a mixed meal and the GLP-1 response is greater than to glucose alone indicating synergy in the stimulation by fat and protein along with glucose (1, 78, 132)

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Therefore, high localized concentrations of metformin may have contributed to the consequence of side effects such as gastrointestinal distress

All patients must be evaluated by a licensed provider, who determines whether medication is clinically appropriate for you