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At The Care Pharmacy, our UK pharmacists provide clear guidance, safe treatment pathways, and personalised support for people considering GLP-1 options

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Preclinical studies have identified that GLP-1 analogs such as exendin-4 and GLP-1RAs have direct anti-atherosclerotic and anti-inflammatory effects that may contribute to their cardio- and neuroprotective nature.[42] GLP-1RAs can also directly interact with cardiomyocytes, inducing receptor-mediated ischemic conditioning that decreases myocardial infarct size in test animals receiving GLP-1RAs.[43] Similar effects were noted in rodent brains, with liraglutide reducing cerebral infarct volume in rats.[42] Randomized clinical trials (RCTs) also identified that exenatide similarly reduced myocardial infarct size and liraglutide reduced the resulting necrotic area in human patients following a MI.[43] This may account for the reduced need for coronary revascularization in patients on GLP-1RAs.[12] Despite the findings of overall improvements to composite cardiovascular outcomes, GLP-1RAs showed a non-significant trend toward reducing MI risk and did not affect rates of hospitalization for unstable angina in patients with diabetes.[12] These agents tend to have a stronger effect on stroke reduction in such patients, highlighting the complexity and variability of cardiovascular disease and its sequelae

The most significant changes were observed at the highest dosages of tirzepatide, i.e., 10 and 15 mg [89, 90]

Mounjaro is only approved to help improve blood sugar levels in adults with type-2 diabetes, but licensed healthcare providers can prescribe it off-label for weight loss

After eating, GLP-1 peptides helps stimulate insulin secretion when blood sugar is high and helps cells absorb sugar from the blood