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After stroke, autonomic imbalance can include relatively increased sympathetic drive with reduced parasympathetic (vagal) tone, which is linked to gastrointestinal dysmotility and may contribute to constipation, intestinal stasis, and conditions favoring bacterial overgrowth (

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3.3 Cyclophosphamide CYC is a well-established alkylating agent widely used in the treatment of severe manifestations of SLE, particularly lupus nephritis (LN) (Zhang et al., 2014)