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TGF-1, like oxidative stress, may have tumor suppressor or promoter effects in cancer [239]

doi: 10.1016/j.celrep.2021.110171 30 Pombo AntunesARScheyltjensILodiFMessiaenJAntoranzADuerinckJet al

Moreover, we demonstrated that neuroinflammatory mechanisms including gasdermin-mediated pyroptosis play important roles in the neurodegenerative process in GCLC-KO mice

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These may act as signaling metabolites with anti-tumor effects by engaging G-protein receptors and inhibiting class-I histone deacetylases, altering gene expression, and dampening PI3KAKT-mTOR signaling 354,355