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While there is a general decrease in global CpG methylation, occasional events activate previously repressed oncogenes

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Alternatively, two of the substituents on adjacent atoms of aryl or heteroaryl ring may optionally be replaced with a substituent of the formula -A-(CH 2 ) r B, wherein A and B are independently CRR, O, NR, S, S(O), S(O) 2 , S(O) 2 NR or a single bond, and r is an integer of from 1 to 4