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Description
Molecular and Cellular Endocrinology , 489 , 3244
Why study this combination
At standard doses of 1 mg or less daily, side effect rates were similar to placebo
Furthermore, a reduction in NAD levels would result in decreased activity of sirtuins, such as SIRT3 (mitochondrial sirtuin), leading to less deacetylation and, consequently, less activation of SOD2 (210)
Anaphylactic shock and death have been reported after parenteral Vitamin B 12 administration
The therapy has been extensively studied and used safely for decades
