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DOI: 10.2174/1570159X13666160502153022

American Conference of Governmental Industrial Hygienists (ACGIH)

However, some conjugated metabolites can be directly cytotoxic because of their ability to inhibit enzymes important for cell viability, as well as by inhibition of the conjugating enzymes

T., Ucan U., Boyacioglu M., Ipek E., et al

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The catalytic tetrad formed by Sec, glutamine, tryptophan and asparagine is essential for GPx activity, since these residues are crucial for enzyme-substrate interaction and stabilization of the GSH-GPx interaction [47, 65, 66]