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No pathological alterations were observed in these groups

doi: 10.1016/0006-2952(91)90363-A

Subsequently, the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) Working Group approach was used to evaluate the certainty of the evidence for each identified treatment modality on a per outcome basis (Supplementary Information: Appendix B) [16]

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Safety Advisory: A dose-dependent increase in the risk of atrial fibrillation has been consistently observed in major trials, especially at the 4 g/day dose, prompting regulatory safety advisories ( Guideline Recommendations: Based on this evidence, major guidelines now endorse the selective use of icosapent ethyl

doi: 10.1016/j.mce.2010.05.019