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Furthermore, studies have reported an aberrant activation of NRF2, a key antioxidant transcription factor involved in the regulation of critical antioxidants including glutathione, SOD, and CAT, leading to reduced antioxidant capacity (Hirayama et al., 2020)

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Declaration of Generative AI tool AI tool has been used to strengthen the language of the review

Applying this dual-effect concept uniformly to specific disease stages, such as the transition from viral hepatitis to HCC, oversimplifies the complex interplay of intracellular signaling and microenvironmental factors, which can vary substantially between patients

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Studies indicate that the ferroptosis-related gene CARS is a potential immune-infiltration-related regulator of ferroptosis